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Natrox™ Oxygen Wound Healing


NATROX® Oxygen Wound Therapy System is a class II medical device licensed under Medical Device Directive 93/42/EEC. The system consists of two main elements; the NATROX® Oxygen Generator and the NATROX® Oxygen delivery system.

The NATROX® Oxygen Generator is a battery-operated device which delivers 98% pure humidified oxygen to the wound bed through water electrolysis. It is supplied with two rechargeable batteries and a charging kit, thus allowing the user complete freedom of movement. Each battery will last for a minimum of 30 hours ; however, users should be advised to keep one on charge whilst using the other and changing them over daily.

The NATROX® Oxygen Delivery System is a sterile, single-use wound interface. Its “web” like design allows free passage of wound exudate into the secondary dressing whilst optimising the flow and diffusion of oxygen across the wound bed. It has a 1 m long thin flexible tube which connects directly to the NATROX® Oxygen Generator. The NATROX® Oxygen Delivery System should be changed at each dressing change in accordance with good clinical practice. However, it can remain in place for up to 7 days if clinically appropriate.

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THE ROLE OF OXYGEN

In Wound Healing

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Case Studies

Hospital Kuala Lumpur, Dr Harichandran K.R. Nair

Patient 1

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Patient Demographics

  • 81 years old, male Pertinent medical history
  • HPT, DFU, Left big toe abscess.
  • Diabetes and have been taking oral medication for the past 20 years.
  • Social history: Works in government sector and retired

Wound Characteristics

  • DFU was developed with left big toe 2 degree abscess for 2 months
  • HPT, DFU, Left big toe abscess.Dressing is changed weekly after incision and drainage, debridement was done to remove slough
  • Initial size: 4.5 cm (L) x 3.5 cm (W)
  • Duration of wound and cause

Treatment Regime

  • Mesitran soft honey act as antibacterial to rehydrate wound
  • HNanogene medication is used as antibacterial gel
  • Betaplast, plain gauze and crepe bandage

Clinical Outcomes

  • Patient started Natrox on February 2018, wound debridement and undermined done . Wound reduction seen after a month . Dressing is changed twice every week
  • After 2 months, dressing is changed one every week.
  • 91 days of total length of treatment
  • Wound reduction is obvious after a month, exudate reduced and granulation with epithelialization are seen
  • 2 months later, biofilm or sloughy surface disappear.

Conclusion

  • Patient is happy that he finally healed after 4 months of Natrox treatment.
  • Patient is able to wear his favourite shoes

Patient 2

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Patient Demographics

  • 61 years old, Male, Divorcee
  • Diabetic oral medication, diet control
  • Diabetic since 1994

Wound Characteristics

  • 6 months old wound is not healed after amputation of the left big toe and then acquired infection
  • Patient was prescribed with oral Unasyn for 3/52
  • Initial size : 9 cm (L) x 6 cm (W)
  • Biofilm was present
  • It is serous with moderate exudate and granulation tissue

Treatment Regime

  • Dressing is changed twice weekly after the Incision, drainage and debridement for slough tissue for the first 3 months
  • 4th months onwards it became a weekly change
  • Dressing regime: Stimulen, Betalast, plain gauze and crepe bandage
  • Barrier cream for skin.

Clinical Outcomes

  • Dressing with Natrox treatment weekly
  • Natrox treatment for the length of 5 months

Conclusion

  • Patient felt that Natrox treatment is simple and cost effective

Patient 1

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Patient Demographics

  • 89 years old, female

Wound Characteristics

  • Wound on 4th toe of left foot with size of 1.43 cm2
  • The toe ulcer presented for three weeks initially 100% covered with eschar.
  • Eschar had been removed in first debridement but slough and biofilm persisted
  • Ankle Brachial Index (ABPI): 0.95

Clinical Outcomes

  • Pain score decreased from 6 to 1.
  • Slough softened and could be removed easily.
  • Slough and biofilm reduced significantly.
  • Topical Oxygen therapy used for only three weeks and the wound healed up three weeks afterwards.

Conclusion

  • Patient is happy that he finally healed after 4 months of Natrox treatment.
  • Patient is able to wear his favourite shoes

Patient 2

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Patient Demographics

  • 90 years old, male
  • Diabetic oral medication, diet control
  • Diabetic since 1994

Wound Characteristics

  • Two pressure ulcers over lateral side of right foot sized 2.88cm² & 5.75cm² respectively
  • Both wounds presented for 1 months and 100% covered with eschar
  • Debridement performed

Clinical Outcomes

  • Pain score decreased from 7 to 1
  • De-sloughing effect is significant
  • Wound size decreased by over 80% in 10 weeks’ time

Conclusion

  • Patient felt that Natrox treatment is simple and cost effective

Ramkhamhaeng Hospital, Dr. Suthas Horsirimanont

Patient 1

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Patient Demographics

  • 73 years old, male

Wound Characteristics

  • Pressure Ulcer was deep inside the Sacrum (about 4mm deep)
  • Ongoing

Clinical Outcomes

  • Depth at Day 20 decreased to 3mm deep
  • Depth at Day 32 decreased to 2.5mm deep.
  • Height of wound decreased from 2.5mm in diameter to 2mm in diameter

Conclusion

  • Patient is happy that he finally healed after Natrox treatment.

Patient 2

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Patient Demographics

  • 78 years old, female Pertinent medical history.
  • Patient has history of SLE (Systemic Lupus Erythematosus) which makes healing difficult
  • Patient acquired wound 4 months ago after amputation of right toe.

Wound Characteristics

  • Depth-3mm Area-14.9cmsq
  • Lymphovascular Venous Stasis

Clinical Outcomes

  • Measurements on Day 22: Depth-2mm Area-12.7cmsq
  • Status is ongoing, but visible improvements can be seen on the wound with wound size decreasing, phase of inflammation has taken place in around week 2 and now exudate has decreased.

Conclusion

  • Patient felt that Natrox treatment is simple and cost effective.

Dr. Ricardo Quintos, Makati Medical Centre

Patient 1

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Patient Demographics

  • 67 years old, Female

Wound Characteristics

  • Vasculitis

Conclusion

  • Patient is happy that she finally healed after Natrox treatment.

Dr. Hanna Kaufman

Patient 1

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Patient Demographics

  • 56 year old
  • Non-insulin-dependent Diabetes

Wound Characteristics

  • 5 month history of ulceration
  • Trauma wound

Treatment Regime

  • Advanced wound dressings

Conclusion

  • Wound closure in 43 days.